Preferential base pairing modes of T·T mismatches

Guoyun He; Chun Kit Kwok; Sik Lok Lam

doi:10.1016/j.febslet.2011.10.044

Preferential base pairing modes of T·T mismatches

FEBS Lett. 2011 Dec 15;585(24):3953-8. doi: 10.1016/j.febslet.2011.10.044. Epub 2011 Nov 15.

Authors

Guoyun He¹, Chun Kit Kwok, Sik Lok Lam

Affiliation

¹ Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

PMID: 22101148
DOI: 10.1016/j.febslet.2011.10.044

Abstract

It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T·T mismatches with specific type of flanking base pairs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Pair Mismatch*
Base Pairing*
Base Sequence
DNA / chemistry*
DNA / genetics*
Magnetic Resonance Spectroscopy
Thymine*

Substances

DNA
Thymine