Abstract
The Ts65Dn mouse is the best-studied animal model for Down syndrome. In the experiments described here, NMDA-mediated or mGluR-mediated LTD was induced in the CA1 region of hippocampal slices from Ts65Dn and euploid control mice by bath application of 20 µM NMDA for 3 min and 50 µM DHPG for 5 min, respectively. We found that Ts65Dn mice display exaggerated NMDA-induced, but not mGluR-induced, LTD in the CA1 region of the hippocampus compared with euploid control animals. In addition, this abnormal level of LTD can be pharmacologically rescued by the NMDA receptor antagonist memantine.
© 2011 Cold Spring Harbor Laboratory Press
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Disease Models, Animal
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Down Syndrome* / drug therapy
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Down Syndrome* / genetics
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Down Syndrome* / pathology
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Electric Stimulation
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Excitatory Amino Acid Agonists / pharmacology*
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Excitatory Amino Acid Antagonists / therapeutic use*
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / genetics
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Hippocampus / drug effects
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Hippocampus / pathology*
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In Vitro Techniques
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Long-Term Synaptic Depression / drug effects*
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Long-Term Synaptic Depression / genetics
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Memantine / therapeutic use*
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Methoxyhydroxyphenylglycol / analogs & derivatives
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Methoxyhydroxyphenylglycol / pharmacology
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Mice
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Mice, Mutant Strains
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N-Methylaspartate / pharmacology*
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Time Factors
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Trisomy / pathology
Substances
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Excitatory Amino Acid Agonists
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Excitatory Amino Acid Antagonists
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Methoxyhydroxyphenylglycol
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N-Methylaspartate
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3,4-dihydroxyphenylglycol
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Memantine