Novel signaling mechanisms in the ovary during oocyte maturation and ovulation

Mol Cell Endocrinol. 2012 Jun 5;356(1-2):65-73. doi: 10.1016/j.mce.2011.11.002. Epub 2011 Nov 12.


During the peri-ovulatory period, the gonadotropin LH triggers major changes in both the somatic and germ cell compartments of the ovarian follicle. The oocyte completes the meiotic cell cycle to become a fertilizable egg, and dramatic changes in gene expression and secretion take place in the somatic compartment of the follicle in preparation for follicular rupture and oocyte release. The concerted changes are regulated by activation of intracellular signaling pathways as well as paracrine and autocrine regulatory loops. This review will provide a summary of the current knowledge of the molecular events triggered by LH focusing mostly on the signaling pathways required for oocyte maturation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Female
  • Gap Junctions / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Luteinizing Hormone / metabolism
  • Luteinizing Hormone / physiology
  • Meiosis
  • Nucleotides, Cyclic / metabolism
  • Nucleotides, Cyclic / physiology
  • Oocytes / metabolism
  • Oocytes / physiology*
  • Ovary / cytology
  • Ovary / metabolism*
  • Ovulation / metabolism*
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction*


  • Intracellular Signaling Peptides and Proteins
  • Nucleotides, Cyclic
  • Receptors, G-Protein-Coupled
  • Luteinizing Hormone