Abstract
Human serum transferrin has a potential for drug-delivery systems. Oxalate and aziridine-carboxylate was conjugated to serum transferrin in order to transport into the targeted cancer cells via transferrin-receptor mediated endocytosis. Capillary zone electrophoresis and capillary isoelectric focusing were used to analyze the effectiveness of complexation reactions. The electropherograms show the differences between iron-free- and iron-complexed molecular forms of human serum transferrin. The iron-complexed transferrin sample containing the different anions as synergistic complexing agents were characterized by different electrophoretic parameters.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anions / chemistry*
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Anions / metabolism
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Aziridines / chemistry
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Aziridines / metabolism
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Aziridines / pharmacology
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Biological Transport
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Cell Line, Tumor
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Drug Delivery Systems
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Electrophoresis, Capillary
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Humans
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Iron / chemistry*
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Iron / metabolism
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Isoelectric Focusing
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Oxalates / chemistry
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Oxalates / metabolism
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Oxalates / pharmacology
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Protein Binding
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Transferrin / chemistry*
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Transferrin / metabolism
Substances
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Anions
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Antineoplastic Agents
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Aziridines
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Oxalates
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Transferrin
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aziridine-2-carboxylic acid
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Iron