Structure of New Delhi metallo-β-lactamase 1 (NDM-1)

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1160-4. doi: 10.1107/S1744309111029654. Epub 2011 Sep 6.


Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-β-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocatalysis
  • Crystallography, X-Ray
  • Klebsiella pneumoniae / enzymology*
  • Models, Molecular
  • Protein Structure, Tertiary
  • beta-Lactamases / chemistry*


  • beta-Lactamases
  • beta-lactamase NDM-1

Associated data

  • PDB/3ZR9