Abstract
The double and simultaneous molecular interaction between antigen-presentig cells (APC) and T lymphocytes is essential for the optimal activation of the immunological response and requires the participation of two membrane receptor groups. Abatacept is a fusion protein that selectively modulates one of these two ways, by binding to CD80 and CD86 receptors on APC. In this way, the drug inhibits T cell activation, selectively blocking the specific interaction of CD80/CD86 receptors to CD28 and, therefore, inhibiting T cell proliferation and B cell immunological response. This pharmacological action results in the normalization of inflammatory mediators in rheumatoid arthritis patients and in a safe and efficacious clinical response. Abatacept in combination with methotrexate prevents the progression of joint damage and improves physical function in rheumatoid arthritis patients.
Copyright © 2011 Elsevier España, S.L. All rights reserved.
MeSH terms
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Abatacept
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Animals
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Antigen Presentation / drug effects*
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Antigen-Presenting Cells / drug effects*
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Antigen-Presenting Cells / immunology
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Antirheumatic Agents / administration & dosage
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Antirheumatic Agents / metabolism
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Antirheumatic Agents / pharmacology*
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Antirheumatic Agents / therapeutic use
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Arthritis, Rheumatoid / drug therapy
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Arthritis, Rheumatoid / immunology
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B-Lymphocytes / immunology
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B7-1 Antigen / immunology
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B7-1 Antigen / metabolism
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B7-2 Antigen / immunology
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B7-2 Antigen / metabolism
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Binding, Competitive
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CD28 Antigens / immunology
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CD28 Antigens / metabolism
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CTLA-4 Antigen / chemistry
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CTLA-4 Antigen / physiology
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Clinical Trials as Topic
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Drug Evaluation, Preclinical
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Humans
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Immunoconjugates / administration & dosage
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Immunoconjugates / metabolism
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Immunoconjugates / pharmacology*
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Immunoconjugates / therapeutic use
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / therapeutic use
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Lymphocyte Activation
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Methotrexate / administration & dosage
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Methotrexate / therapeutic use
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Mice
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Models, Immunological
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T-Cell Antigen Receptor Specificity
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology
Substances
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Antirheumatic Agents
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B7-1 Antigen
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B7-2 Antigen
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CD28 Antigens
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CD86 protein, human
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CTLA-4 Antigen
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CTLA4 protein, human
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Immunoconjugates
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Immunosuppressive Agents
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Abatacept
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Methotrexate