Effect of ulcerative colitis and smoking on rectal blood flow

Gut. 1990 Sep;31(9):1021-4. doi: 10.1136/gut.31.9.1021.


Rectal blood flow was measured by laser doppler flowmetry over 60 minutes in eight patients with colitis in remission and eight healthy male non-smokers. Ten smokers were also examined on two occasions, one of which included smoking a cigarette. Plasma nicotine concentrations were measured in smokers. All subjects showed a pronounced fall in rectal blood flow in the first 30 minutes and patients with colitis had significantly higher values compared with smokers (p less than 0.002; p less than 0.04) and non-smokers (p less than 0.007; p less than 0.002) during the first and second 30 minutes respectively. Values in smokers and non-smokers were similar, but smoking a cigarette was associated with a significant fall in blood flow (p less than 0.04) and this change was inversely related to the rise in plasma nicotine concentration (r = -0.63; p less than 0.05). The findings may be relevant to the association between colitis and the smoking history.

MeSH terms

  • Adult
  • Aged
  • Blood Flow Velocity
  • Colitis, Ulcerative / etiology
  • Colitis, Ulcerative / physiopathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nicotine / blood
  • Rectum / blood supply*
  • Regional Blood Flow
  • Smoking / physiopathology*


  • Nicotine