Effectiveness of a herbal formula in women with menopausal syndrome

Forsch Komplementmed. 2011;18(5):264-8. doi: 10.1159/000333430. Epub 2011 Oct 10.


Background: Lady 4 is a combination of 4 natural components (evening primrose oil, damiana, ginseng, royal jelly) with a known history of traditional use for menopausal symptoms.

Objective: To study efficacy and safety of Lady 4 in women suffering from menopausal syndrome.

Methods: 120 women with menopausal symptoms were randomised into an experimental group treated with 2 capsules of Lady 4 daily and a control group treated with placebo. The outcome was measured by the Menopause Rating Scale II (MRS-II).

Results: There was a statistically significant improvement in the MRS-II score in both groups after 2 and 4 weeks of treatment, but the improvement was significantly better in the Lady 4 group (p < 0.001). 86.7% in the Lady 4 group and 56.7% in the placebo group rated the therapy success as 'much improved' or 'very much improved'.

Conclusion: Lady 4 may be beneficial in the treatment of menopausal syndrome and can be used as a safe natural promoter of health and well-being in women during the menopausal transition.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Female
  • Humans
  • Menopause*
  • Middle Aged
  • Phytotherapy / standards*
  • Plant Extracts / therapeutic use*
  • Syndrome
  • Treatment Outcome


  • Plant Extracts