Synthesis of new class of alkyl azarene pyridinium zwitterions via iodine mediated sp3 C-H bond activation

Org Lett. 2011 Dec 16;13(24):6366-9. doi: 10.1021/ol202654j. Epub 2011 Nov 22.

Abstract

An efficient and conceptually different approach toward C-H bond activation by using iodine mediated sp(3) C-H functionalization for the synthesis of alkyl azaarene pyridinium zwitterions is described. This work has the interesting distinction of being the first synthesis of a new class of alkyl azaarene pyridinium zwitterion via transition-metal-free sp(3) C-H bond activation of an alkyl azaarene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aza Compounds / chemistry*
  • Catalysis
  • Iodides
  • Iodine / chemistry*
  • Molecular Structure
  • Pyridinium Compounds / chemical synthesis*
  • Pyridinium Compounds / chemistry*

Substances

  • Aza Compounds
  • Iodides
  • Pyridinium Compounds
  • Iodine