Nanoporous polymeric nanofibers based on selectively etched PS-b-PDMS block copolymers

ACS Appl Mater Interfaces. 2012 Jan;4(1):280-5. doi: 10.1021/am201331b. Epub 2011 Dec 13.

Abstract

One-dimensional nanoporous polymeric nanofibers have been fabricated within an anodic aluminum oxide (AAO) membrane by a facile approach based on selective etching of poly(dimethylsiloxane) (PDMS) domains in polystyrene-block-poly(dimethylsiloxane) (PS-b-PDMS) block copolymers that had been formed within the AAO template. It was observed that prior to etching, the well-ordered PS-b-PDMS nanofibers are solid and do not have any porosity. The postetched PS nanofibers, on the other hand, had a highly porous structure having about 20-50 nm pore size. The nanoporous polymeric fibers were also employed as a drug carrier for the native, continuous, and pulsatile drug release using Rhodamine B (RB) as a model drug. These studies showed that enhanced drug release and tunable drug dosage can be achieved by using ultrasound irradiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aluminum Oxide / chemistry
  • Dimethylpolysiloxanes / chemistry*
  • Drug Carriers / chemistry*
  • Drug Delivery Systems / instrumentation*
  • Nanofibers / chemistry*
  • Polymers / chemical synthesis*
  • Polymers / chemistry
  • Polystyrenes / chemistry*
  • Porosity
  • Rhodamines / chemistry
  • Rhodamines / pharmacokinetics

Substances

  • Dimethylpolysiloxanes
  • Drug Carriers
  • Polymers
  • Polystyrenes
  • Rhodamines
  • baysilon
  • rhodamine B
  • Aluminum Oxide