Frequency of the F508 Deletion in the CFTR Gene in Turkish Cystic Fibrosis Patients

Hum Genet. 1990 Sep;85(4):409-10. doi: 10.1007/BF02428283.


The F508 deletion in the cystic fibrosis transmembrane conductance regulator (CFTR) gene was found in 8 out of 30 Turkish cystic fibrosis (CF) chromosomes (27%). Five Turkish delta F508 CF chromosomes were associated with the risk haplotype B in KM19 (2 allele)/XV2c (1 allele). In the Turkish population, cystic fibrosis is predominantly caused by mutations other than the F508 deletion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Deletion*
  • Cystic Fibrosis / epidemiology
  • Cystic Fibrosis / genetics*
  • Gene Frequency
  • Humans
  • Mutation
  • Turkey / epidemiology