Rotavirus vaccines: update on global impact and future priorities

Hum Vaccin. 2011 Dec;7(12):1282-90. doi: 10.4161/hv.7.12.18321. Epub 2011 Dec 1.


Early rotavirus vaccine adopter countries in the Americas, Europe, and in Australia have documented substantial declines in rotavirus disease burden following the introduction of vaccination. However, the full public health impact of rotavirus vaccines has not been realized as they have not been introduced into routine immunization programs in countries of Africa and Asia with the highest rotavirus disease morbidity and mortality burden. In this article, we review the epidemiology of rotavirus disease, the development and current status of rotavirus vaccines including newly available vaccine impact data from early-introducer countries, and future priorities for implementation and monitoring of rotavirus vaccination programs in developing countries.

Publication types

  • Review

MeSH terms

  • Child, Preschool
  • Developing Countries
  • Gastroenteritis / epidemiology*
  • Gastroenteritis / mortality
  • Gastroenteritis / prevention & control
  • Gastroenteritis / virology
  • Humans
  • Immunization Programs / statistics & numerical data*
  • Infant
  • Rotavirus / immunology*
  • Rotavirus Infections / epidemiology*
  • Rotavirus Infections / mortality
  • Rotavirus Infections / prevention & control
  • Rotavirus Infections / virology
  • Rotavirus Vaccines / immunology
  • Rotavirus Vaccines / therapeutic use*
  • Vaccination


  • Rotavirus Vaccines