The HPV vaccine impact monitoring project (HPV-IMPACT): assessing early evidence of vaccination impact on HPV-associated cervical cancer precursor lesions

Cancer Causes Control. 2012 Feb;23(2):281-8. doi: 10.1007/s10552-011-9877-6. Epub 2011 Nov 23.


The following paper describes a collaboration between the Centers for Disease Control and Prevention and five Emerging Infections Program sites to develop a comprehensive population-based approach to monitoring human papillomavirus (HPV) vaccine impact on cervical cancer precursors and associated HPV genotypes. The process of establishing this novel monitoring system is described, and development details such as enumeration of sources for reporting cervical intraepithelial neoplasia 2/3 and adenocarcinoma in situ, approaches to case ascertainment, electronic reporting, and HPV typing are outlined. Implementation of a feasible and sustainable surveillance system for HPV-associated cervical precancers will enable evaluation of the direct impact of HPV vaccination.

MeSH terms

  • Adenocarcinoma / immunology
  • Adenocarcinoma / prevention & control
  • Adolescent
  • Adult
  • Cervical Intraepithelial Neoplasia / immunology*
  • Cervical Intraepithelial Neoplasia / prevention & control*
  • Cervical Intraepithelial Neoplasia / virology
  • Female
  • Genotype
  • Humans
  • Papillomaviridae / immunology
  • Papillomavirus Vaccines / immunology*
  • Pilot Projects
  • Precancerous Conditions / immunology*
  • Precancerous Conditions / prevention & control*
  • Prospective Studies
  • Uterine Cervical Neoplasms / immunology*
  • Uterine Cervical Neoplasms / prevention & control*
  • Uterine Cervical Neoplasms / virology
  • Young Adult


  • Papillomavirus Vaccines