The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage

Chem Commun (Camb). 2012 Jan 14;48(4):585-7. doi: 10.1039/c1cc16538k. Epub 2011 Nov 23.

Abstract

In contrast to the usual inclusion of disulfide bonds within a polymer structure to facilitate bio-degradation, we have designed a self-curing "one pot" hyperbranched polymer capable of forming crosslinked gels under reducing conditions abundant in tumoural tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival
  • Disulfides / chemistry*
  • Disulfides / metabolism
  • Gels / chemistry*
  • Gels / metabolism
  • Mice
  • NIH 3T3 Cells
  • Oxidation-Reduction
  • Polymers / chemistry*
  • Polymers / metabolism

Substances

  • Disulfides
  • Gels
  • Polymers