Abstract
A new polyene macrolide antibiotic, YS-822A was isolated from the culture filtrate of a mutant strain H-8 of Streptoverticillium eurocidicum var. asterocidicus S-822. Whereas the original S-822 strain produced not only YS-822 substances but also teleocidin as by-product which is well-known as a strong carcinogenic promoter, the mutagenized H-8 strain produced the antibiotic with only a trace amount of teleocidin. Chemical and biological characterizations of the antibiotic revealed that YS-822A (molecular formula: C37H59NO14) is a new polyene macrolide with a wide antifungal spectrum and a low acute toxicity.
MeSH terms
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Animals
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Anti-Bacterial Agents / biosynthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / biosynthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Chromatography
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Drug Stability
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Female
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Fermentation
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Fungi / drug effects*
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Hydrogen-Ion Concentration
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Macrolides*
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Mice
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Mice, Inbred ICR
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Molecular Structure
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Mutation
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Solubility
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Spectrophotometry
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Streptomycetaceae / genetics
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Streptomycetaceae / isolation & purification
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Streptomycetaceae / metabolism*
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Macrolides
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YS 822A