Simaomicin (LL-D42067), a novel antibiotic from Actinomadura madurae. I. Taxonomy, fermentation and biological activity

J Antibiot (Tokyo). 1990 Sep;43(9):1059-63. doi: 10.7164/antibiotics.43.1059.

Abstract

A new antibacterial antibiotic, designated simaomicin alpha (LL-D42067 alpha) was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-D42067 was identified as a new subspecies of Actinomadura madurae. Simaomicin alpha demonstrated potent activity against Gram-positive bacteria and was active in vivo against a variety of Eimeria species causing coccidiosis in chickens.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / pharmacology
  • Chickens / parasitology
  • Coccidiosis / drug therapy
  • Coccidiosis / veterinary*
  • Coccidiostats / pharmacology*
  • Coccidiostats / therapeutic use
  • Fermentation
  • Gram-Positive Bacteria / drug effects*
  • Isoquinolines / pharmacology
  • Isoquinolines / therapeutic use
  • Male
  • Molecular Structure
  • Nocardiaceae / classification
  • Nocardiaceae / metabolism*
  • Poultry Diseases / drug therapy*
  • Soil Microbiology

Substances

  • Anti-Bacterial Agents
  • Coccidiostats
  • Isoquinolines
  • simaomicin alpha