Abstract
A new antibacterial antibiotic, designated simaomicin alpha (LL-D42067 alpha) was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-D42067 was identified as a new subspecies of Actinomadura madurae. Simaomicin alpha demonstrated potent activity against Gram-positive bacteria and was active in vivo against a variety of Eimeria species causing coccidiosis in chickens.
MeSH terms
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Animals
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Anti-Bacterial Agents / biosynthesis*
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Anti-Bacterial Agents / pharmacology
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Chickens / parasitology
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Coccidiosis / drug therapy
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Coccidiosis / veterinary*
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Coccidiostats / pharmacology*
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Coccidiostats / therapeutic use
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Fermentation
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Gram-Positive Bacteria / drug effects*
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Isoquinolines / pharmacology
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Isoquinolines / therapeutic use
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Male
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Molecular Structure
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Nocardiaceae / classification
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Nocardiaceae / metabolism*
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Poultry Diseases / drug therapy*
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Soil Microbiology
Substances
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Anti-Bacterial Agents
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Coccidiostats
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Isoquinolines
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simaomicin alpha