Vitamin d deficiency in patients with chronic liver disease and cirrhosis

Curr Gastroenterol Rep. 2012 Feb;14(1):67-73. doi: 10.1007/s11894-011-0231-7.

Abstract

Vitamin D is now widely recognized to have multiple extraskeletal health functions. The liver is one of the major organs involved in its metabolism. Recent studies have demonstrated a very high prevalence of vitamin D deficiency and insufficiency in patients with chronic liver disease and cirrhosis. There is an emerging interest to explore the relationship between vitamin D deficiency and prevalence and severity of non-alcoholic liver disease and response to antiviral therapy in hepatitis C. In this review, we discuss the current status of our understanding of vitamin D metabolism and vitamin D deficiency in patients with chronic liver disease and cirrhosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Chronic Disease
  • Humans
  • Liver Cirrhosis / complications*
  • Liver Cirrhosis / metabolism
  • Liver Diseases / complications*
  • Liver Diseases / metabolism
  • Vitamin D Deficiency / etiology*
  • Vitamin D Deficiency / metabolism