Remineralization of early enamel lesions using casein phosphopeptide amorphous calcium Phosphate: an ex-vivo study

Contemp Clin Dent. 2010 Oct;1(4):210-3. doi: 10.4103/0976-237X.76385.


Objective: This study aimed at qualitatively evaluating the remineralization potential of casein phosphopeptide amorphous calcium phosphate on artificial early enamel lesions in an ex-vivo scenario by observing the treated tooth surface using a scanning electron microscope (SEM).

Materials and methods: This randomized study was conducted on 10 subjects undergoing orthodontic treatment with premolar extraction as part of their treatment. Artificial white lesions were created with the application of 37% phosphoric acid for 20 mins. Teeth were then divided into two groups: one experimental and the other control. Customised orthodontic band with a window was luted with intermediate restorative material in the experimental group whereas in the control group, band without a window was luted. The casein phosphopeptide amorphous calcium phosphate (GC TOOTH MOUSSE) paste was then applied on the window region of the experimental group for 3 mins thrice daily after meals for 14 days, whereas no paste was applied in the control group. After 14 days, teeth were extracted and viewed under an SEM.

Results: The study groups showed remineralization of the lesions as compared with the control group in most of the samples.

Conclusion: Casein phophopeptide could significantly remineralize the artificial enamel lesions in vivo.

Keywords: Enamel remineralisation; casein-phosphopeptide amorphous calcium phosphate.