The penetration of roxithromycin into human skin

J Antimicrob Chemother. 1990 Jul;26(1):87-90. doi: 10.1093/jac/26.1.87.

Abstract

The skin penetration of roxithromycin was studied in 27 surgical patients treated with 300 mg orally followed by three oral doses of 150 mg 12-hourly. Peak plasma and skin concentrations of 7.9 +/- 1.2 mg/l and 31.3 +/- 3.7 mg/kg occurred 2.5 and 4 h after last dosing respectively. The plasma and skin half-lives were 7.7 and 6.0 h, and the mean plasma and skin area under the curve values were 64.3 mg/l.h and 155.3 mg/kg.h. Skin/plasma concentration ratios were 4.9 +/- 0.5, 9.7 +/- 1.2, 7.6 +/- 0.8 and 5.9 +/- 1.1, at 3, 4, 5 and 6 h after last dosing respectively. These results demonstrate that roxithromycin achieves high levels in human skin.

MeSH terms

  • Female
  • Half-Life
  • Humans
  • Male
  • Middle Aged
  • Roxithromycin / pharmacokinetics*
  • Skin Absorption*

Substances

  • Roxithromycin