Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients

S McCormick; J Olin; A W Brotman

Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients

J Clin Psychiatry. 1990 Sep;51(9):383-4.

Authors

S McCormick¹, J Olin, A W Brotman

Affiliation

¹ Erich Lindemann Mental Health Center, Boston, MA 02114.

PMID: 2211550

Abstract

The authors report two cases of ejaculatory dysfunction induced by fluoxetine. Cyproheptadine, an antihistaminic and antiserotonergic drug, restored sexual function in each case. Possible mechanisms of fluoxetine-induced anorgasmia are presented and treatment options are reviewed.

Publication types

Case Reports

MeSH terms

Adult
Cyproheptadine / therapeutic use*
Depressive Disorder / drug therapy
Ejaculation / drug effects
Fluoxetine / adverse effects*
Humans
Male
Middle Aged
Orgasm / drug effects*
Sexual Dysfunctions, Psychological / chemically induced*
Sexual Dysfunctions, Psychological / drug therapy

Substances

Fluoxetine
Cyproheptadine