Synthesis and antihyperlipidemic activity of acetylated derivative of ulvan from Ulva pertusa

Int J Biol Macromol. 2012 Jan 1;50(1):270-2. doi: 10.1016/j.ijbiomac.2011.11.006. Epub 2011 Nov 17.

Abstract

In this study, acetylated ulvan (AU) was prepared with acetic anhydride in N,N-dimethylacetamide, and the antihyperlipidemic activity of natural ulvan and its acetylated ulvan derivative (AU) in mice was determined. Obvious differences in antihyperlipidemic activity between natural ulvan and its derivative were observed, moreover, AU showed stronger antihyperlipidemic activity on triglyceride (TG) and low density lipoprotein cholesterol (LDL-C).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Animals
  • Cholesterol / chemistry
  • Cholesterol, LDL / chemistry*
  • Female
  • Hyperlipidemias / drug therapy*
  • Male
  • Mice
  • Models, Statistical
  • Nicotinic Acids / chemistry
  • Plant Extracts / pharmacology
  • Polysaccharides / chemistry
  • Polysaccharides / metabolism*
  • Polysaccharides / pharmacology
  • Temperature
  • Triglycerides / chemistry*
  • Ulva / metabolism*

Substances

  • Cholesterol, LDL
  • Nicotinic Acids
  • Plant Extracts
  • Polysaccharides
  • Triglycerides
  • ulvan
  • Cholesterol
  • Inositol Niacinate