Management of corneal perforation

Surv Ophthalmol. Nov-Dec 2011;56(6):522-38. doi: 10.1016/j.survophthal.2011.06.003.


Corneal perforation may be associated with prolapse of ocular tissue and requires prompt diagnosis and treatment. Although infectious keratitis is an important cause, corneal xerosis and collagen vascular diseases should be considered in the differential diagnosis, especially in cases that do not respond to conventional medical therapy. Although medical therapy is a useful adjunct, a surgical approach is required for most corneal perforations. Depending on the size and location of the corneal perforation, treatment options include gluing, amniotic membrane transplantation, and corneal transplantation.

Publication types

  • Review

MeSH terms

  • Amnion / transplantation*
  • Biological Dressings
  • Corneal Perforation / diagnosis
  • Corneal Perforation / etiology
  • Corneal Perforation / therapy*
  • Corneal Transplantation*
  • Humans
  • Tissue Adhesives / therapeutic use*


  • Tissue Adhesives