Kinesins lead aging microtubules to catastrophe

Cell. 2011 Nov 23;147(5):966-8. doi: 10.1016/j.cell.2011.11.011.


The ability of growing microtubules to undergo catastrophes--abrupt switches from growth to shortening--is one of the key aspects of microtubule dynamics important for shaping cellular microtubule arrays. Gardner et al. show that catastrophes occur at a microtubule age-dependent rate and that depolymerizing kinesins can affect this process in fundamentally different ways.

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