Intravital imaging

Cell. 2011 Nov 23;147(5):983-91. doi: 10.1016/j.cell.2011.11.004.


Until recently, the idea of observing life deep within the tissues of a living mouse, at a resolution sufficient to pick out cellular behaviors and molecular signals underlying them, remained a much-coveted dream. Now, a new era of intravital fluorescence microscopy has dawned. In this Primer, we review the technologies that made this revolution possible and demonstrate how intravital imaging is beginning to provide quantitative and dynamic insights into cell biology, immunology, tumor biology, and neurobiology.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Communication
  • Humans
  • Mice
  • Molecular Imaging / methods*
  • Neoplasm Metastasis / pathology
  • Neoplasms / blood supply
  • Neoplasms / pathology