Natural course of epilepsy concomitant with CNS tuberculomas

Epilepsy Res. 2012 Mar;99(1-2):107-11. doi: 10.1016/j.eplepsyres.2011.10.032. Epub 2011 Nov 26.


Background: Epilepsy is relatively common in CNS tuberculomas, but its natural course is unclear.

Aim: To determine the prevalence and prognosis of epilepsy in patients with seizures related to CNS tuberculomas.

Methods: We retrospectively reviewed the charts of patients with CNS tuberculomas who presented at our institution between 1983 and 2001.

Results: Seizures occurred in 22 of 93 (23.6%) of the patients with CNS tuberculomas. These patients were treated with standard antituberculous therapy for a period varying between 6 and 20 months. Sixty-three out of 93 patients were cured of tuberculosis, and 21 of the 63 (33%) who had concomitant epilepsy became seizure-free. TB recurred in 3 patients, and 1 out of 22 who had concomitant epilepsy continued to have seizures; 3 died and 24 were lost to follow-up. Anti-epileptic medications were discontinued after completion of the anti-TB course.

Conclusion: Seizures are commonly associated with CNS tuberculomas and most often resolve after successful treatment of the underlying CNS tuberculosis.

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Epilepsy / drug therapy
  • Epilepsy / epidemiology*
  • Epilepsy / pathology*
  • Female
  • Humans
  • Male
  • Retrospective Studies
  • Tuberculoma, Intracranial / drug therapy
  • Tuberculoma, Intracranial / epidemiology*
  • Tuberculoma, Intracranial / pathology*


  • Antitubercular Agents