Open spina bifida: birth findings predict long-term outcome

Arch Dis Child. 2012 May;97(5):474-6. doi: 10.1136/archdischild-2011-300624. Epub 2011 Nov 25.

Abstract

Objectives: To investigate if lifestyle in spina bifida at age 40±3 years, relates to neurological deficit in infancy or cerebrospinal fluid shunt history.

Design: Prospective cohort study with 100% ascertainment.

Setting: Community.

Participants: 117 consecutive cases of open spina bifida whose backs were closed non-selectively at birth. In 2007, all 46 (39%) survivors and/or carers were surveyed by postal questionnaires and telephone interviews.

Results: Of the 38 children with absent sensation only below the knee (sensory level below L3), 23 (61%) survived of whom 14 (61%) were community walkers and only 5 (22%) needed daily care. But in 42 babies with absent sensation up to the umbilicus (sensory level above T11) only seven (17%) survived, none could walk and five (71%) needed daily care. Survivors with no shunt revisions were more likely to walk, live independently and drive a car.

Conclusion: Mobility and the need for care at 40 can be predicted from the neurological deficit.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Cerebrospinal Fluid Shunts
  • Disability Evaluation
  • Employment
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Kaplan-Meier Estimate
  • Life Style
  • Male
  • Prognosis
  • Sensation Disorders / etiology
  • Severity of Illness Index
  • Spina Bifida Cystica / complications
  • Spina Bifida Cystica / rehabilitation*
  • Spina Bifida Cystica / surgery
  • Treatment Outcome