Twenty years of Alzheimer's disease-causing mutations

J Neurochem. 2012 Jan;120 Suppl 1:3-8. doi: 10.1111/j.1471-4159.2011.07575.x. Epub 2011 Nov 28.

Abstract

In this study, we review our finding of APP mutations in Alzheimer's disease in 1990-1991 with the benefit of 20 years' perspective. We discuss the historical context in which we made the finding, its immediate and continuing effects on research activity and our hopes for successful clinical testing of the hypothesis. We also briefly discuss the effects finding APP mutations has had on our own careers and those of our colleagues from 1991.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / etiology*
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Amyloid beta-Protein Precursor / chemistry
  • Amyloid beta-Protein Precursor / genetics*
  • Animals
  • Genetic Loci
  • Humans
  • Mutation / genetics*
  • Plaque, Amyloid / chemistry
  • Plaque, Amyloid / etiology
  • Plaque, Amyloid / genetics

Substances

  • Amyloid beta-Protein Precursor