Immunogenicity of delayed TBE-vaccine booster

Vaccine. 2012 Jan 11;30(3):499-502. doi: 10.1016/j.vaccine.2011.11.061. Epub 2011 Nov 26.

Abstract

Information is scarce regarding the antibody response when TBE-vaccine booster doses are delayed, which is a common situation in daily life. We have investigated the immune response after a delayed booster dose compared to a normal booster interval in an every-day setting. Overall, 250/260 (96%) of the study participants had neutralizing antibodies post-booster, with no significant difference between normal and delayed booster intervals. Based on our findings we propose that healthy individuals who have failed adherence to the recommended schedule of TBE-vaccination can be given a delayed dose without concern of immunogenicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Neutralizing / blood
  • Antibodies, Viral / blood
  • Encephalitis Viruses, Tick-Borne / immunology*
  • Encephalitis, Tick-Borne / prevention & control*
  • Female
  • Humans
  • Immunization, Secondary / methods*
  • Male
  • Middle Aged
  • Viral Vaccines / administration & dosage*
  • Viral Vaccines / immunology*
  • Young Adult

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Viral Vaccines