A battle for iron: host sequestration and Staphylococcus aureus acquisition

Microbes Infect. 2012 Mar;14(3):217-27. doi: 10.1016/j.micinf.2011.11.001. Epub 2011 Nov 15.

Abstract

The use of iron as an enzymatic cofactor is pervasive in biological systems. Consequently most living organisms, including pathogenic bacteria, require iron to survive and replicate. To combat infection vertebrates have evolved sophisticated iron sequestration systems against which, pathogenic bacteria have concomitantly evolved equally elaborate iron acquisition mechanisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Gene Expression Regulation, Bacterial
  • Heme / metabolism
  • Heme Oxygenase (Decyclizing) / metabolism
  • Hemoglobins / metabolism*
  • Host-Pathogen Interactions
  • Humans
  • Iron / metabolism*
  • Siderophores / metabolism
  • Staphylococcal Infections / immunology*
  • Staphylococcal Infections / metabolism
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / immunology
  • Staphylococcus aureus / metabolism*
  • Staphylococcus aureus / pathogenicity
  • Virulence Factors / genetics
  • Virulence Factors / metabolism

Substances

  • Bacterial Proteins
  • Hemoglobins
  • Siderophores
  • Virulence Factors
  • Heme
  • Iron
  • Heme Oxygenase (Decyclizing)