Lithium in the treatment of neutropenia

Curr Opin Hematol. 2012 Jan;19(1):52-7. doi: 10.1097/MOH.0b013e32834da93b.


Purpose of review: The capacity of lithium to induce neutrophilia and increase circulating CD34(+) cells of marrow origin has long been known. Lithium has been the object of hematological investigations for many years, but no definitive use in hematology has yet emerged.

Recent findings: We review the evidence that lithium increases granulocyte colony-stimulating factor (G-CSF) and augments G-CSF effects, showing its potential use in stem cell mobilization and engraftment of stem cell transplantation.

Summary: We suggest possible therapeutic uses of lithium in neutropenia. In bone marrow transplantation, preharvest lithium-assisted hematopoietic stem cell mobilization may be useful as well.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication
  • Review

MeSH terms

  • Granulocyte Colony-Stimulating Factor / metabolism
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Hematopoietic Stem Cell Mobilization / methods
  • Hematopoietic Stem Cell Transplantation / methods
  • Hematopoietic Stem Cells / drug effects
  • Humans
  • Lithium Carbonate / therapeutic use*
  • Neutropenia / drug therapy*
  • Neutropenia / metabolism


  • Granulocyte Colony-Stimulating Factor
  • Lithium Carbonate