Antioxidants in patients receiving total parenteral nutrition after gastrointestinal cancer surgery

Cell Biochem Funct. 2012 Apr;30(3):211-6. doi: 10.1002/cbf.1837. Epub 2011 Nov 29.


Total parenteral nutrition (TPN) is essential for patients with postoperative impairing gastrointestinal function who are unable to receive and absorb oral/enteral feeding for at least 7 days. Oxidative stress plays a major role in the ethiopathogenesis of cancers. In this study, total antioxidant status (TAS), glutathione peroxidase (GPx), superoxide dismutase, malondialdehyde and ascorbic acid were studied in patients operated because of small intestine, colorectal or pancreatic cancer and subsequently receiving TPN in comparison with patients receiving standard nutrition after the operation. TAS level and GPx activity were decreased in patients with small intestine cancer but did not differ in patients with colorectal and pancreatic cancer before and after surgery. In all patient groups receiving TPN, superoxide dismutase activity after the surgery was kept at the same level as before. On the fifth day after the surgery, malondialdehyde concentration in each group was restored to the value observed before surgery. On the fifth day of TPN treatment, ascorbic acid concentration was increased in every group of patients. TPN applied during the postoperative period alleviates oxidative stress resulting from surgery. In the case of small intestine cancer, the addition of vitamins and antioxidants to the nutrition mixture seems to result in depletion of antioxidant enzymes' activities.

Publication types

  • Clinical Trial

MeSH terms

  • Aged
  • Antioxidants / metabolism*
  • Ascorbic Acid / metabolism
  • Digestive System Surgical Procedures
  • Female
  • Gastrointestinal Neoplasms / metabolism
  • Gastrointestinal Neoplasms / surgery
  • Gastrointestinal Neoplasms / therapy*
  • Glutathione Peroxidase / metabolism
  • Humans
  • Male
  • Malondialdehyde / metabolism
  • Middle Aged
  • Oxidative Stress
  • Parenteral Nutrition, Total*
  • Postoperative Care
  • Superoxide Dismutase / metabolism


  • Antioxidants
  • Malondialdehyde
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Ascorbic Acid