The dentine remineralization activity of a desensitizing bioactive glass-containing toothpaste: an in vitro study

Aust Dent J. 2011 Dec;56(4):372-81. doi: 10.1111/j.1834-7819.2011.01361.x. Epub 2011 Oct 13.


Background: Dentine hypersensitivity occurs easily on exposed dentine. This study aimed to evaluate the effectiveness of a novel bioactive glass-containing toothpaste on dentine permeability and remineralization.

Methods: Thirty dentine discs were divided into three groups of 10 specimens each. The groups corresponded to the following brushing treatments: no brush, distilled water, and bioactive glass-containing toothpaste (Novamin). The toothpaste was applied twice a day for 7 days. Dentine permeability was measured after ethylene-diamine-tetraacetic acid (EDTA) etching, initial application, 3-day application, 7-day application and citric acid challenge, respectively. The dentine morphology was investigated using scanning electron microscopy (SEM). Attenuated total reflection Fourier transform infrared (ATR/FTIR) spectroscopy was performed to monitor the mineral variation on demineralized dentine. Qualitative information of elemental variation before and after treatments on completely demineralized dentine was detected by energy dispersive X-ray (EDX) analysis.

Results: The bioactive glass-containing toothpaste significantly reduced dentine permeability after the 7-day treatment and showed, under SEM, excellent resistance to acid challenge compared to the other groups. ATR/FTIR and EDX revealed increased mineral content after treatment with Novamin.

Conclusions: As the innovative bioactive glass-containing toothpaste occlude dentinal tubules and resist acid challenge, it may be useful for the treatment of dentine hypersensitivity and dentine remineralization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Calcium / analysis
  • Dentin Desensitizing Agents / therapeutic use*
  • Dentin Permeability / drug effects*
  • Dentin Sensitivity / drug therapy*
  • Glass*
  • Humans
  • Microscopy, Electron, Scanning
  • Phosphates / analysis
  • Spectrometry, X-Ray Emission
  • Spectroscopy, Fourier Transform Infrared / methods
  • Tooth Remineralization / methods*
  • Toothpastes / pharmacology
  • Toothpastes / therapeutic use*


  • Dentin Desensitizing Agents
  • NovaMin
  • Phosphates
  • Toothpastes
  • Calcium