Vitamin C Intake From Diary Recordings and Risk of Breast Cancer in the UK Dietary Cohort Consortium

Eur J Clin Nutr. 2012 May;66(5):561-8. doi: 10.1038/ejcn.2011.197. Epub 2011 Nov 30.

Abstract

Background/objectives: Vitamin C intake has been inversely associated with breast cancer risk in case-control studies, but not in meta-analyses of cohort studies using Food Frequency Questionnaires, which can over-report fruit and vegetable intake, the main source of vitamin C. This is the first study to investigate associations between vitamin C intake and breast cancer risk using food diaries.

Subjects/methods: Estimated dietary vitamin C intake was derived from 4-7 day food diaries pooled from five prospective studies in the UK Dietary Cohort Consortium. This nested case-control study of 707 incident breast cancer cases and 2144 matched controls examined breast cancer risk in relation to dietary vitamin C intake using conditional logistic regression adjusting for relevant covariates. Additionally, total vitamin C intake from supplements and diet was analysed in three cohorts.

Results: No evidence of associations was observed between breast cancer risk and vitamin C intake analysed for dietary vitamin C intake (odds ratios (OR)=0.98 per 60 mg/day, 95% confidence interval (CI): 0.88-1.09, P (trend)=0.7), dietary vitamin C density (OR=0.97 per 60 mg/day, 95% CI: 0.87-1.07, P (trend)=0.5 ) or total vitamin C intake (OR=1.01 per 60 mg/day, 95% CI: 0.99-1.03, P (trend)=0.3). Additionally, there was no significant association for post-menopausal women (OR=1.02 per 60 mg/day, 95% CI: 0.99-1.05, P (trend)=0.3).

Conclusions: This pooled analysis of individual UK women found no evidence of significant associations between breast cancer incidence and dietary or total vitamin C intake derived uniquely from detailed diary recordings.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Ascorbic Acid / pharmacology*
  • Ascorbic Acid / therapeutic use
  • Breast Neoplasms / prevention & control*
  • Case-Control Studies
  • Diet Records
  • Diet*
  • Energy Intake*
  • Female
  • Humans
  • Logistic Models
  • Middle Aged
  • Nutrition Assessment*
  • Odds Ratio
  • Postmenopause
  • Prospective Studies
  • Risk Factors
  • United Kingdom

Substances

  • Ascorbic Acid