Congeneric lantibiotics from ribosomal in vivo peptide synthesis with noncanonical amino acids

Angew Chem Int Ed Engl. 2012 Jan 9;51(2):415-8. doi: 10.1002/anie.201106154. Epub 2011 Nov 30.

Abstract

Expanded repetoire: Synthetic amino acids translated into propeptides dramatically increase the chemical diversity of the two-component lantibiotic lichenicidin. This opens new routes towards novel and unique peptide antibiotic sequences, which could display features important for medical applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Amino Acids / genetics
  • Amino Acids / metabolism*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / metabolism*
  • Bacillus / chemistry
  • Bacillus / genetics
  • Bacillus / metabolism*
  • Bacteriocins / chemistry
  • Bacteriocins / genetics
  • Bacteriocins / metabolism*
  • Cloning, Molecular
  • Escherichia coli / genetics
  • Escherichia coli / metabolism*
  • Gene Expression
  • Models, Molecular
  • Protein Processing, Post-Translational
  • Ribosomes / genetics
  • Ribosomes / metabolism*

Substances

  • Amino Acids
  • Anti-Bacterial Agents
  • Bacteriocins
  • lichenicidin, Bacillus licheniformis