An overview of the c-MET signaling pathway

Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S7-S19. doi: 10.1177/1758834011422556.


c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth factor, activates a wide range of different cellular signaling pathways, including those involved in proliferation, motility, migration and invasion. Although c-MET is important in the control of tissue homeostasis under normal physiological conditions, it has also been found to be aberrantly activated in human cancers via mutation, amplification or protein overexpression. This paper provides an overview of the c-MET signaling pathway, including its role in the development of cancers, and provides a rationale for targeting the pathway as a possible treatment option.

Keywords: MET; c-MET; cancer; hepatocyte growth factor (HGF); receptor tyrosine kinase; signaling.