A single dose of armodafinil significantly promotes vigilance 11 hours post-dose

Mil Med. 2011 Jul;176(7):833-9. doi: 10.7205/milmed-d-10-00250.


Objective: This study was conducted to test the ability of armodafinil to promote vigilance among air traffic control operators 8 to 11 hours post-dose.

Methods: Forty-eight U.S. Naval air traffic control students were assigned to one of two groups, 150 mg dose of armodafinil or placebo. At 8:00 a.m., participants were administered armodafinil or a placebo, after which they completed a standard work day. Participants returned at 3:45 p.m. to complete the 4-hour performance portion of the study, where they performed the psychomotor vigilance task.

Results: The analysis showed a significant difference in vigilance between the armodafinil group and placebo (p < 0.05). Psychomotor vigilance task data revealed that participants receiving a 150 mg dose of armodafinil experienced significantly fewer lapses of attention compared to the control group.

Conclusions: These results justify additional investigation into the efficacy of armodafinil to promote sustained vigilance in military operational settings where fatigue-related performance decrements are especially problematic.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aerospace Medicine*
  • Arousal
  • Attention
  • Benzhydryl Compounds / administration & dosage*
  • Central Nervous System Stimulants / administration & dosage*
  • Dose-Response Relationship, Drug
  • Fatigue / prevention & control*
  • Female
  • Humans
  • Male
  • Military Personnel
  • Modafinil
  • Psychomotor Performance
  • Young Adult


  • Benzhydryl Compounds
  • Central Nervous System Stimulants
  • Modafinil