Indices of central aortic blood pressure and their impact on cardiovascular outcomes

J Cardiovasc Med (Hagerstown). 2012 Jan;13(1):38-45. doi: 10.2459/JCM.0b013e32834ead20.

Abstract

Elevated peripheral (brachial) blood pressure (PBP) is related to hard cardiovascular outcomes and remains the main target for antihypertensive therapy. However, central aortic blood pressure (CABP) can be measured noninvasively and could potentially prove to be a more important marker of cardiovascular diseases in future. Several studies have shown association of CABP with cardiovascular mortality, coronary artery disease, left-ventricular hypertrophy and atherosclerosis. Furthermore, the impact of various classes of antihypertensive agents on CABP is different from their impact on PBP. We review the significance of CABP in cardiovascular outcomes and the differential impact of antihypertensive therapy on CABP.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Aorta / drug effects
  • Aorta / physiopathology*
  • Blood Pressure Determination
  • Blood Pressure* / drug effects
  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / drug therapy
  • Cardiovascular Diseases / mortality
  • Cardiovascular Diseases / physiopathology*
  • Elasticity
  • Humans
  • Predictive Value of Tests
  • Pulsatile Flow
  • Treatment Outcome

Substances

  • Antihypertensive Agents