Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation - revelation of B cell developmental pathways and lineage phenotypes

Clin Exp Immunol. 2012 Jan;167(1):15-25. doi: 10.1111/j.1365-2249.2011.04469.x.


Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we discuss the current knowledge of humoral problems and B cell development after HSCT, and relate these to the current understanding of human peripheral B cell development. We describe how these studies have aided the identification of subsets of transitional B cells and also a robust memory B cell phenotype.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibody Formation
  • Antigens, Differentiation, B-Lymphocyte / analysis
  • B-Lymphocyte Subsets / cytology*
  • Cell Lineage
  • Graft Survival
  • Hematopoietic Stem Cell Transplantation*
  • Hematopoietic Stem Cells / cytology*
  • Humans
  • Immunocompromised Host
  • Immunologic Memory
  • Immunophenotyping
  • Infections / etiology
  • Leukocyte Common Antigens / biosynthesis
  • Lymphopenia / etiology
  • Lymphopoiesis / physiology*
  • Mice
  • Transplantation Conditioning / adverse effects


  • Antigens, Differentiation, B-Lymphocyte
  • Leukocyte Common Antigens