Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 48 (5), 690-2

Regiospecific β-Lactam Ring-Opening/Recyclization Reactions of N-aryl-3-spirocyclic-β-lactams Catalyzed by a Lewis-Brønsted Acids Combined Superacid Catalyst System: A New Entry to 3-spirocyclicquinolin-4(1H)-ones

Affiliations

Regiospecific β-Lactam Ring-Opening/Recyclization Reactions of N-aryl-3-spirocyclic-β-lactams Catalyzed by a Lewis-Brønsted Acids Combined Superacid Catalyst System: A New Entry to 3-spirocyclicquinolin-4(1H)-ones

Yinqiao Hu et al. Chem Commun (Camb).

Abstract

The regiospecific β-lactam ring-opening/recyclization reaction of N-aryl-3-spirocyclic-β-lactams, made by the one-pot cyclization reaction of acetoacetanilides, has been achieved for the first time using a Lewis-Brønsted acids combined superacid catalyst system, thus providing an efficient entry to 3-spirocyclicquinolin-4(1H)-ones. A mechanism involving superacid-catalysis was proposed.

Similar articles

See all similar articles

Cited by 1 article

Publication types

LinkOut - more resources

Feedback