Risk of prostate cancer in a population-based cohort of men with coeliac disease

Br J Cancer. 2012 Jan 3;106(1):217-21. doi: 10.1038/bjc.2011.536. Epub 2011 Dec 1.


Background: Prostate cancer (PC) is a leading cause of fatal cancer in men in developed countries. Coeliac disease (CD) has previously been linked to a raised cancer risk, and changes in some exposures following a CD diagnosis might hypothetically raise PC risk.

Methods: We identified 10,995 patients with CD who had undergone a small intestinal biopsy in 1969-2007. Statistics Sweden then identified 54,233 age-matched male reference individuals from the general population. PC data were obtained from the Swedish Cancer Register. Hazard ratios (HRs) for PC were estimated using Cox regression analysis.

Results: During follow-up, 185 individuals with CD (expected n=200) had an incident diagnosis of PC. This corresponds to a HR of 0.92 (0.79-1.08) (with 95% confidence interval) and an absolute risk reduction of 15/100,000 person-years among those with CD. An increased risk was not observed even when identification of PC began 5 years after biopsy.

Conclusion: Our conclusion is that a CD diagnosis does not represent an increased risk for PC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biopsy
  • Celiac Disease / epidemiology*
  • Celiac Disease / pathology
  • Cohort Studies
  • Humans
  • Male
  • Proportional Hazards Models
  • Prostatic Neoplasms / complications
  • Prostatic Neoplasms / epidemiology*
  • Risk Factors