Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila

EMBO Rep. 2011 Dec 23;13(1):83-9. doi: 10.1038/embor.2011.223.


Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally maintains blood progenitors can sense oxidative stress and regulate the cellular immune response. Pathogen infection induces ROS in the niche cells, resulting in the secretion of an epidermal growth factor-like cytokine signal that leads to the differentiation of specialized cells involved in innate immune responses.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Drosophila / immunology*
  • Drosophila / metabolism
  • Drosophila Proteins / metabolism
  • Epidermal Growth Factor / metabolism
  • Forkhead Transcription Factors / metabolism
  • Hematopoiesis / immunology*
  • Immunity, Cellular / immunology*
  • Membrane Proteins / metabolism
  • Oxidative Stress*
  • Proto-Oncogene Proteins c-akt / metabolism
  • Reactive Oxygen Species / metabolism
  • Stem Cell Niche / immunology*


  • Drosophila Proteins
  • FOXO protein, Drosophila
  • Forkhead Transcription Factors
  • Membrane Proteins
  • Reactive Oxygen Species
  • spi protein, Drosophila
  • Epidermal Growth Factor
  • Akt1 protein, Drosophila
  • Proto-Oncogene Proteins c-akt