Aromatase inhibitors in the treatment of recurrent ovarian granulosa cell tumors: brief report and review of the literature

J Obstet Gynaecol Res. 2012 Jan;38(1):340-4. doi: 10.1111/j.1447-0756.2011.01698.x. Epub 2011 Dec 5.


Granulosa cell tumors are ovarian sex cord stromal cancers that are unique for their indolent nature and late recurrence. Standard treatment regimens utilized include surgery, chemotherapy, and radiotherapy. However, hormonal suppression with aromatase inhibitors, which have shown promising results, may be a viable alternative to these modalities. We present a heavily pre-treated, multi-operated patient who experienced significant tumor shrinkage following treatment with an aromatase inhibitor for her recurrent granulosa cell tumor.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Aromatase Inhibitors / therapeutic use*
  • Female
  • Granulosa Cell Tumor / drug therapy*
  • Granulosa Cell Tumor / pathology
  • Humans
  • Neoplasm Recurrence, Local / drug therapy*
  • Neoplasm Recurrence, Local / pathology
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / pathology
  • Treatment Outcome


  • Aromatase Inhibitors