Treadmill testing improves survival prediction models in pulmonary arterial hypertension

Chih-Hsin Hsu; Cherylanne Glassner; Aimee J Foreman; Richa Agarwal; Raymond J Benza; Robert P Frantz; Mardi Gomberg-Maitland

doi:10.1016/j.ahj.2011.09.015

Treadmill testing improves survival prediction models in pulmonary arterial hypertension

Am Heart J. 2011 Dec;162(6):1011-7. doi: 10.1016/j.ahj.2011.09.015. Epub 2011 Nov 8.

Authors

Chih-Hsin Hsu¹, Cherylanne Glassner, Aimee J Foreman, Richa Agarwal, Raymond J Benza, Robert P Frantz, Mardi Gomberg-Maitland

Affiliation

¹ Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

PMID: 22137074
DOI: 10.1016/j.ahj.2011.09.015

Abstract

Background: Six-minute walk distance (6MWD) is used in the REVEAL equation to predict 1-year survival for patients with pulmonary arterial hypertension. We sought to determine whether exercise treadmill testing (ETT) could be used in its place.

Methods: This was a single-center study in which 449 patients were enrolled. The variables predictive of survival in the REVEAL equation were evaluated and compared with survival predicted by the REVEAL equation without an exercise measure and a revised equation using ETT.

Results: The addition of ETT to the equation improved the predictive ability of the REVEAL equation in the high- and low-risk patient groups.

Conclusion: The study findings suggest that the addition of ETT parameters to the REVEAL prognostic equation improves the predictive value of the equation when 6-minute walk distance is unavailable.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Exercise Test*
Female
Humans
Hypertension, Pulmonary / diagnosis
Hypertension, Pulmonary / mortality*
Male
Middle Aged
Models, Statistical
Predictive Value of Tests
Prognosis
Survival Analysis