Neurally adjusted ventilatory assist in neonates weighing <1500 grams: a retrospective analysis

J Pediatr. 2012 May;160(5):786-9.e1. doi: 10.1016/j.jpeds.2011.10.014. Epub 2011 Dec 3.


Objective: To report our experience using neurally adjusted ventilatory assist (NAVA), which allows a patient to synchronize spontaneous respiratory effort with mechanical ventilation, in the neonatal intensive care unit in neonates weighing <1500 g.

Study design: This was a retrospective review performed between May 2008 and May 2009. A total of 52 neonates on conventional ventilation were converted to NAVA. We compared ventilatory parameters and blood gas values during conventional ventilation and then at various time intervals during NAVA and evaluated for complications. Statistical analyses were performed using the 2-tailed Student t-test and the Z-test for proportions for demographic data and Hotelling's T(2) test to compare repeated measures (P < .05).

Results: Peak inspiratory pressure and fraction of inspired oxygen decreased, and pH and partial pressure of carbon dioxide improved during use of NAVA. These changes were sustained for 24 hours.

Conclusion: Compared with standard conventional ventilation, in preterm neonates NAVA appears to provide better blood gas regulation with lower peak inspiratory pressure and oxygen requirements.

Publication types

  • Comparative Study

MeSH terms

  • Blood Gas Analysis
  • Cohort Studies
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Very Low Birth Weight*
  • Intensive Care Units, Neonatal*
  • Interactive Ventilatory Support / methods*
  • Male
  • Oxygen Consumption / physiology*
  • Peak Expiratory Flow Rate
  • Pulmonary Gas Exchange
  • Respiration, Artificial / methods
  • Respiratory Distress Syndrome, Newborn / diagnosis
  • Respiratory Distress Syndrome, Newborn / mortality
  • Respiratory Distress Syndrome, Newborn / therapy*
  • Respiratory Mechanics / physiology
  • Retrospective Studies
  • Risk Assessment
  • Sensitivity and Specificity
  • Survival Rate
  • Treatment Outcome