A review of fish-derived antioxidant and antimicrobial peptides: their production, assessment, and applications

Peptides. 2012 Jan;33(1):178-85. doi: 10.1016/j.peptides.2011.11.013. Epub 2011 Nov 26.


Fishes are rich sources of structurally diverse bioactive compounds. In recent years, much attention has been paid to the existence of peptides with biological activities and proteins derived from foods that might have beneficial effects for humans. Antioxidant and antimicrobial peptides isolated from fish sources may be used as functional ingredients in food formulations to promote consumer health and improve the shelf life of food products. This paper presents an overview of the antioxidant and antimicrobial peptides derived from various fishes. In addition, we discuss the extraction of fish proteins, enzymatic production, and the techniques used to isolate and characterize these compounds. Furthermore, we review the methods used to assay the bioactivities and their applications in food and nutraceuticals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anti-Infective Agents / pharmacology*
  • Antioxidants / pharmacology*
  • Dietary Supplements
  • Fish Proteins / isolation & purification*
  • Fish Proteins / pharmacology*
  • Hydrolysis
  • Molecular Sequence Data
  • Peptides / isolation & purification
  • Peptides / pharmacology*


  • Anti-Infective Agents
  • Antioxidants
  • Fish Proteins
  • Peptides