Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles

FEBS Lett. 2012 Jan 2;586(1):47-54. doi: 10.1016/j.febslet.2011.11.022. Epub 2011 Nov 28.


Increasing amounts of tau protein were expressed in non-neuronal cells. When intracellular amounts reached a threshold level, tau protein was released to the extracellular culture medium in association with membrane vesicles. Hence, we propose that tau might be secreted through membrane vesicles as a cellular mechanism to eliminate the excess of tau protein, thereby avoiding its toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • COS Cells
  • Cell Death
  • Cell Line
  • Chlorocebus aethiops
  • Extracellular Space / metabolism
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Neurons / cytology
  • Neurons / metabolism
  • Organelles / metabolism*
  • tau Proteins / genetics
  • tau Proteins / metabolism*


  • tau Proteins