How the 'slow' Ca(2+) buffer parvalbumin affects transmitter release in nanodomain-coupling regimes

Nat Neurosci. 2011 Dec 4;15(1):20-2. doi: 10.1038/nn.3002.


Parvalbumin is thought to act in a manner similar to EGTA, but how a slow Ca(2+) buffer affects nanodomain-coupling regimes at GABAergic synapses is unclear. Direct measurements of parvalbumin concentration and paired recordings in rodent hippocampus and cerebellum revealed that parvalbumin affects synaptic dynamics only when expressed at high levels. Modeling suggests that, in high concentrations, parvalbumin may exert BAPTA-like effects, modulating nanodomain coupling via competition with local saturation of endogenous fixed buffers.

MeSH terms

  • Animals
  • Cerebellum / physiology*
  • Hippocampus / physiology*
  • Inhibitory Postsynaptic Potentials / physiology
  • Interneurons / physiology*
  • Parvalbumins / metabolism*
  • Rats
  • Synapses / physiology*
  • Synaptic Transmission / physiology
  • gamma-Aminobutyric Acid / metabolism


  • Parvalbumins
  • gamma-Aminobutyric Acid