Transmission of HIV-1 infections from mothers to infants in Haiti. Impact on childhood mortality and malnutrition. The CDS/JHU AIDS Project Team

JAMA. 1990 Oct 24-31;264(16):2088-92.

Abstract

Of 4588 pregnant women in a high-risk Haitian population, 443 (9.7%) were serologically positive for the human immunodeficiency virus type 1 (HIV-1). Infants born to women who were HIV-1 seropositive were more likely to be premature, of low birth weight, and malnourished at 3 and 6 months of age than were infants born to women who were HIV-1 seronegative. Increased mortality was observed in infants born to women who were HIV-1 seropositive by 3 months of age. At 12 months of age, 23.4% of the infants born to women who were HIV-1 seropositive had died compared with 10.8% of the infants born to women who were HIV-1 seronegative; at 24 months of age, the mortality rates were 31.3% and 14.2%, respectively. Maternal HIV-1 infections resulted in an 11.7% increase in the overall infant mortality rate in this population. The estimated mother-to-infant HIV-1 transmission rate in these breast-fed infants was 25%, similar to the rates reported for non-breast-fed populations in the United States and Europe.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Birth Weight
  • Child, Preschool
  • Developing Countries
  • Female
  • HIV Infections / epidemiology
  • HIV Infections / mortality
  • HIV Infections / transmission*
  • HIV Seropositivity / epidemiology
  • HIV-1*
  • Haiti / epidemiology
  • Humans
  • Infant
  • Infant Mortality*
  • Infant Nutrition Disorders / epidemiology*
  • Infant Nutrition Disorders / mortality
  • Infant, Newborn
  • Infant, Premature, Diseases / epidemiology
  • Infant, Premature, Diseases / mortality
  • Male
  • Nutrition Assessment
  • Pregnancy
  • Pregnancy Complications, Infectious / epidemiology