Monoamines activate neuropeptide signaling cascades to modulate nociception in C. elegans: a useful model for the modulation of chronic pain?

Invert Neurosci. 2012 Jun;12(1):53-61. doi: 10.1007/s10158-011-0127-0. Epub 2011 Dec 6.


Monoamines and neuropeptides interact to modulate key behaviors in most organisms. This review is focused on the interaction between octopamine (OA) and an array of neuropeptides in the inhibition of a simple, sensory-mediated aversive behavior in the C. elegans model system and describes the role of monoamines in the activation of global peptidergic signaling cascades. OA has been often considered the invertebrate counterpart of norepinephrine, and the review also highlights the similarities between OA inhibition in C. elegans and the noradrenergic modulation of pain in higher organisms.

Publication types

  • Review

MeSH terms

  • Animals
  • Behavior, Animal
  • Biogenic Monoamines / metabolism
  • Caenorhabditis elegans / metabolism
  • Chronic Pain / metabolism*
  • Chronic Pain / physiopathology
  • Disease Models, Animal*
  • Neuropeptides / metabolism*
  • Nociception / physiology
  • Octopamine / metabolism*
  • Signal Transduction / physiology*


  • Biogenic Monoamines
  • Neuropeptides
  • Octopamine