Surveillance of pancreatic cancer patients after surgical resection

Ann Surg Oncol. 2012 May;19(5):1670-7. doi: 10.1245/s10434-011-2152-y. Epub 2011 Dec 6.

Abstract

Background: There are no clear recommendations to guide posttreatment surveillance in patients with pancreatic cancer. Our goal was to describe the posttreatment surveillance patterns in patients undergoing curative-intent resection for pancreatic cancer.

Methods: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data (1992-2005) to identify CT scans and physician visits in patients with pancreatic cancer who underwent curative resection (n = 2393). Surveillance began 90 days after surgery, and patients were followed for 2 years at 6-month intervals. Patients were censored if they died, experienced recurrence of disease, or entered hospice.

Results: A total of 2045 patients survived uncensored to the beginning of the surveillance period. CT scan use decreased from 20.9% of patients in month 4 to 6.4% in month 27. There was no temporal pattern in CT use to suggest regular surveillance. Twenty-three percent of patients did not receive a CT scan in the year after surgery, increasing to 42% the second year. Patients who underwent adjuvant therapy and patients diagnosed in later years had higher CT scan use over the surveillance periods. Most patients visited both a primary care physician and a cancer specialist in each 6-month surveillance period. Patients who visited cancer specialists were more likely to have any CT scan and to be scanned more frequently.

Conclusions: Current surveillance patterns after resection for pancreatic cancer reflect the lack of established guidelines, implying a need for evaluation and standardization of surveillance protocols. The lack of a temporal pattern in CT testing suggests that most were obtained to evaluate symptoms rather than for routine surveillance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / diagnostic imaging
  • Adenocarcinoma / epidemiology*
  • Adenocarcinoma / secondary
  • Adenocarcinoma / surgery*
  • Aged
  • Cause of Death
  • Chemoradiotherapy, Adjuvant
  • Cohort Studies
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Medicare / statistics & numerical data*
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / epidemiology*
  • Office Visits / statistics & numerical data
  • Pancreatic Neoplasms / diagnostic imaging
  • Pancreatic Neoplasms / epidemiology*
  • Pancreatic Neoplasms / surgery*
  • Population Surveillance
  • Postoperative Period
  • Survival Rate
  • Tomography, X-Ray Computed
  • United States / epidemiology